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Z. Naturforsch. 2013,
68b, 1259 – 1264
doi:10.5560/ZNB.2013-3168
Depsidones from an Endophytic Fungus Chaetomium sp. Associated with Zanthoxylum leprieurii
1 Institute of Organic and Biomolecular Chemistry, Georg-August University, Tammannstr. 2, D-37077 Göttingen, Germany
2 Institute of Biology, University of Kassel, Heinrich-Plett-Strasse 40, D-34132 Kassel, Germany
Reprint requests to Prof. Dr. Hartmut Laatsch. Tel.: +49/551/3933211. Fax: +49/551/399660. E-mail:
hlaatsc@gwdg.de
Received June 17, 2013 / published online November 4, 2013
A new depsidone, namely chaetosidone A (1), together with six known fungal metabolites were obtained from a culture of Chaetomium sp., an endophytic fungus isolated from Zanthoxylum leprieurii leaves. The structure of the new compound 1 was elucidated using MS and NMR experiments, and by biosynthetic considerations. Chaetosidone A (1) is the missing link in the series of orsellinic acid-derived depsidones. Compound 1, corynesidone B (2) and corynether (3) displayed inhibitory effects on two Gram-positive bacteria, Bacillus subtilis and Staphylococcus aureus, at concentrations of 40 μg per paper disk and moderate toxicity towards brine shrimp larvae (Artemia salina).
Key words: Endophyte, Chaetomium sp., Depsidones, Toxicity, Antimicrobial Activity
Supporting Material: