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Z. Naturforsch.
69c, 375 – 380
(2014)
doi:10.5560/ZNC.2014-0066
Antibacterial Flavanones and Dihydrochalcones from Macaranga trichocarpa
1 Organic Chemistry Division, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung 40132, Indonesia. E-mail:
yana@chem.itb.ac.id
2 Microbiology Laboratory, Health Polytechnique, Jalan Babakan Loa, Cimahi 40514, Indonesia
*Author for correspondence and reprint requests
Received March 27 / October 2, 2014 / published online November 18, 2014
Previously we had isolated two prenylated flavanones and two prenylated dihydrochalcones, macatrichocarpins A–D (1–4), from the acetone extract of the leaves of Macaranga trichocarpa. Reexamination of the fractions containing minor components resulted in the isolation of four more flavonoid derivatives, including two new prenylated dihydrochalcones, oxymacatrichocarpin C (5) and isomacatrichocarpin C (6). The structures of these compounds were determined by the analysis of UV, NMR, and mass spectral data. The eight isolated flavonoids were tested on eight pathogenic bacteria and found to be mostly moderate antibacterial agents, with the lowest MIC value of 26.5 μm achieved by the flavanone macatrichocarpin A (1) against Bacillus subtilis.
Key words: Antibacterials, Isomacatrichocarpin C, Oxymacatrichocarpin C, Macaranga trichocarpa