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Z. Naturforsch.
69c, 283 – 290
(2014)
doi:10.5560/ZNC.2014-0029
Synthesis and Antimicrobial Activities of Oxazepine and Oxazocine Derivatives
1 Jiangsu Key Laboratory of Biofunctional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210097, China. E-mail: wangbingxiang@njnu.edu.cn
2 Department of Chemistry and Chemical Engineering, Shaoxing University, Shaoxing 312000, China. E-mail:
shenyongmiao@hotmail.com
*Authors for correspondence and reprint requests
Received February 6 / June 21, 2014 / published online August 13, 2014
A series of annulated 7-membered oxazepine and 8-membered oxazocine derivatives were synthesized by photoreaction of phthalimide derivatives and an alkene. The antimicrobial activities of the synthesized compounds were evaluated, and compounds 18 and 20 exhibited best antibacterial activity against Gram-positive bacteria. The relationships between structure (especially steric structure) and antimicrobial activities are discussed.
Key words: Oxazepine, Oxazocine, Antimicrobial Activity, Structure-Activity Relationship