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Z. Naturforsch.
69c, 117 – 123
(2014)
doi:10.5560/ZNC.2013-0088
Cytotoxic Polyacetylenes from the Red Sea Sponge Siphonochalina siphonella
1 Department of Chemistry, Faculty of Science, King Abdulaziz University, P. O. Box 80203, Jeddah 21589, Saudi Arabia. Fax: +966 2 6951599. E-mail:
snayyad2@yahoo.com
2 Permanent address: Department of Chemistry, Faculty of Science, Damietta University, Damietta, Egypt
3 Department of Marine Chemistry, Faculty of Marine Sciences, King Abdulaziz University, P. O. Box 80207, Jeddah 21589, Saudi Arabia
4 Forensic Chemistry Laboratory at Mansoura, Ministry of Justice, Mansoura, Egypt
5 Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt
*Author for correspondence and reprint requests
Received May 5, 2013 / January 25, 2014 / published online April 2, 2014
Two new polyacetylenes, callyspongenol-D (1) and callyspongendiol (2), the known polyacetylene dehydrosiphonochalynol (3), and the known triterpenoid sipholenol-A (4) were isolated from the Red Sea sponge Siphonochalina siphonella. Their chemical structures were elucidated on the basis of spectroscopic analyses. The cytotoxicity of the isolated compounds towards the human mammary carcinoma cell line MCF-7 was determined by the lactate dehydrogenase (LDH) assay, and compounds 4 and 1 were found to be the most toxic of the four, with IC50 values of 8.8 and 11.7 μm, respectively.
Key words: Red Sea, Marine Sponges, Breast Cancer