|
Z. Naturforsch.
69c, 92 – 98
(2014)
doi:10.5560/ZNC.2013-0111
Non-Alkaloidal Compounds from the Bulbs of the Egyptian Plant Pancratium maritimum
1 Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt
2 Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia. Fax: +966-269-516-96. E-mail:
dyoussef@kau.edu.sa
3 Department of Pharmacognosy, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt
4 Natural Products Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia
5 Suez Canal University, Ismailia 41522, Egypt
*Author for correspondence and reprint requests
Received June 30 / December 20, 2013 / published online April 16, 2014
Phytochemical investigation of the cytotoxic fractions of fresh bulbs of Pancratium maritimum L. led to the isolation and structure identification of two new compounds, pancricin (1) and pancrichromone (4), together with four known compounds, including 2,4-dihydroxy-6-methoxy-3-methyl acetophenone (2), 5-formylfurfuryl acetate (3), 7-β-d-glucosyloxy-5-hydroxy-2-methylchromone (5), and ethyl-β-d-glucopyranoside (6). Their structures were established on the basis of 1D and 2D NMR spectroscopy (1H, 13C, COSY, HSQC, and HMBC), as well as HR mass spectral analyses. The compounds were evaluated for their antimigratory and antiproliferative activities against the highly metastatic human prostate cancer cell line
(PC-3M). Compound 5 was the most active compound displaying good activity in the proliferation assay comparable to that of the positive control 4-hydroxyphenylmethylene hydantoin, while it displayed only weak antimigratory activity compared to the positive control 4-ethylmercaptophenylmethylene hydantoin.
Key words: Amaryllidaceae, Pancratium maritimum, Antimigratory and Antiproliferative Activities