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Z. Naturforsch.
69c, 68 – 74
(2014)
doi:10.5560/ZNC.2013-0035
Low-Dose Radiation Suppresses Pokemon Expression under Hypoxic Conditions
1 Department of Emergency Medicine, Chungnam National University Hospital, Taejon 301-721, Korea
2 Korea Research Institute of Bioscience & Biotechnology, Taejon 305-806, Korea
3 Department of Biomedical Laboratory Science, College of Health & Welfare, Kyungwoon University, Gumi 730-739, Korea
4 Department of Emergency Medicine, Daegu Fatima Hospital, Daegu 701-600, Korea
5 Department of Anatomy, College of Medicine, Chungnam National University, Taejon 301-747, Korea. Fax: +82-42-586-4800. E-mail:
oykwon@cnu.ac.kr
*Authors for correspondence and reprint requests
Received February 26 / December 2, 2013 / published online March 5, 2014
Our previous data demonstrated that CoCl2-induced hypoxia controls endoplasmic reticulum (ER) stress-associated and other intracellular factors. One of them, the transcription factor Pokemon, was differentially regulated by low-dose radiation (LDR). There are limited data regarding how this transcription factor is involved in expression of the unfolded protein response (UPR) under hypoxic conditions. The purpose of this study was to obtain clues on how Pokemon is involved in the UPR. Pokemon was selected as a differentially expressed gene under hypoxic conditions; however, its regulation was clearly repressed by LDR. It was also demonstrated that both expression of ER chaperones and ER stress sensors were affected by hypoxic conditions, and the same results were obtained when cells in which Pokemon was up- or down-regulated were used. The current state of UPR and LDR research associated with the Pokemon
pathway offers an important opportunity to understand the oncogenesis, senescence, and differentiation of cells, as well as to facilitate introduction of new therapeutic radiopharmaceuticals.
Key words: Low-Dose Radiation (LDR), Hypoxia, Pokemon