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Z. Naturforsch. 2014,
69b, 742 – 746
doi:10.5560/ZNB.2014-4059
Two Rare Hydroazulene-type Sesquiterpenes from the Roots of Aristolochia yunnanensis
1 Pharmacy Department, Medical School, Foshan University, Foshan 528000, P. R. China
2 The 5th People's Hospital of Foshan City, Foshan 528211, P. R. China
3 The 2nd People's Hospital of Foshan, Foshan 528000, P. R. China
4 The School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, P. R. China
Reprint requests to Prof. Feng-Ni Wen. Fax: +86757-86882001. E-mail:
wfniys@126.com or
wfniys@163.com
Received March 6, 2014 / published online June 7, 2014
Two new sesquiterpenes, named aristoyunnolin I (1) and J (2), together with eight known compounds (3–10) were isolated from the roots of Aristolochia yunnanensis. Compounds 1 and 2 feature a rare hydroazulene-type sesquiterpene skeleton and represent the third and fourth examples of this kind found in nature. The structures were determined from spectroscopic data, and the absolute configurations of 1–3 were assigned by comparing experimental with simulated electronic circular dichroism (ECD) spectra. Compounds 1, 2, 6–10 were isolated from this plant for the first time. The cytotoxic activities of 1–10 were evaluated against P-388 and A-549 cell lines. Only compounds 4 and 5 showed moderate activity with IC50 values ranging from 12.0 to 18.2 μm.
Key words: Aristolochia yunnanensis, Aristoyunnolin, Hydroazulene-type Sesquiterpene, Cytotoxic Activities
Supporting Material: