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Z. Naturforsch. 2014,
69b, 715 – 720
doi:10.5560/ZNB.2014-4026
One-pot Multi-component Synthesis of Mono- and Bis-indolylimidazole Derivatives Using Zn2+@KSF and Their Antibacterial Activity
1 Department of Chemistry, Faculty of Science, University of Guilan, P. O. Box 41335-1914, Rasht, I. R. Iran
2 Laboratory of Microbiology and Immunology of Infectious Diseases, Paramedicine Faculty, Guilan University of Medical Sciences, P. O. Box 44715-1361, Guilan, I. R. Iran
Reprint requests to Prof. Nosrat O. Mahmoodi. Fax: +98-131-3233262. E-mail:
mahmoodi@guilan.ac.ir and
nosmahmoodi@gmail.com
Received February 2, 2014 / published online June 7, 2014
The preparation of mono- and bis-indolylimidazole derivatives using Zn2+ supported on montmorillonite KSF (Zn2+@KSF) as an efficient heterogeneous catalyst is described. The structures of these compounds were characterized by IR, 1H NMR and 13C NMR spectroscopy. The antibacterial activity of the selected products was examined. Some products exhibit promising activities.
Key words: Zn2+@KSF, Clay Catalyst, Bis-indole, Indolylimidazole, Multicomponent Reaction (MCR)