Z. Naturforsch. 2013,
68b, 362 – 366
doi:10.5560/ZNB.2013-2323
TiO2 Nanoparticles as an Efficient Catalyst for the One-pot Preparation of Tetrahydrobenzo[c]acridines in Aqueous Media
Shahrzad
Abdolmohammadi,
Mahdieh
Mohammadnejad and
Faezeh
Shafaei
Department of Chemistry, Faculty of Science, East Tehran Branch, Islamic Azad University, P. O. Box 33955-163, Tehran, I. R. Iran
Received December 7, 2012; in revised form January 25, 2013 / published online April 19, 2013
A series of tetrahydrobenzo[c]acridinone derivatives have been prepared by a one-pot four-component reaction of 1-naphthol, aromatic aldehydes, dimedone, and ammonium acetate in aqueous media using a catalytic amount of titanium dioxide nanoparticles (TiO2 NPs). The advantages of this novel protocol include the excellent yields, operational simplicity, short reaction time, easy work-up, reusability of the catalyst and an environmentally friendly procedure.
Key words: Aqueous Media, Domino Knoevenagel-Michael Condensation, Tetrahydrobenzo[c]acridinones, TiO2 Nanoparticles