Z. Naturforsch. 2013,
68b, 257 – 266
doi:10.5560/ZNB.2013-2339
Synthesis, Crystal Structure, DNA-binding Properties and Antioxidant Activities of a Lutetium(III) Complex with the Bis(N-salicylidene)-3-oxapentane-1,5-diamine Ligand
Guolong
Pan,
Yuchen
Bai,
Hua
Wang,
Jin
Kong,
Furong
Shi,
Yanhui
Zhang,
Xiaoli
Wang, and
Huilu
Wu
School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou 730070, P. R. China
Received December 27, 2012 / published online March 20, 2013
A Schiff base ligand bis(N-salicylidene)-3-oxapentane-1,5-diamine (H2L) and its lutetium(III) complex, with composition Lu2(L)2(NO3)2, were synthesized and characterized by physico-chemical and spectroscopic methods. The crystal structure of the Lu(III) complex has been determined by single-crystal X-ray diffraction. It reveals a centrosymmetric binuclear neutral entity where Lu(III) metal centers are bridged by two phenoxo oxygen atoms. The DNA-binding properties of the Lu(III) complex were investigated by spectrophotometric methods and viscosity measurements, and the results suggest that the Lu(III) complex binds to DNA via a groove binding mode. Additionally, the antioxidant activity of the Lu(III) complex was determined by the superoxide and hydroxyl radical scavenging methods in
vitro, which indicate that it is a scavenger for OH· and O2−· radicals.
Key words: Lutetium(III) Complex, Crystal Structure, DNA-Binding Properties, Antioxidant Activities, Bis(N-salicylidene)-3-oxapentane-1,5-diamine