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Z. Naturforsch. 2013,
68b, 229 – 238
doi:10.5560/ZNB.2013-2297
Synthesis and anti-HIV Activity of New Fused Chromene Derivatives Derived from 2-Amino-4-(1-naphthyl)-5-oxo-4H,5H-pyrano[3,2-c]chromene-3-carbonitrile
1 Department of Chemistry, College of Science, University of Basrah, Basrah, Iraq. Present address: Am Tannenhof 8, 78464 Konstanz, Germany
2 Institut für Chemie, Universität Rostock, Albert-Einstein-Str. 3a, 18059 Rostock, Germany
3 Department of Chemistry, College of Science, University of Al-Mustansiryah, Baghdad, Iraq
4 Leibniz-Institut für Katalyse an der Universität Rostock e.V., Albert-Einstein-Str. 29a, 18059 Rostock, Germany
5 Rega Institute for Medical Research, Katholieke Universiteit Leuven, B-3000 Leuven, Belgium
Reprint requests to Prof. Peter Langer. E-mail:
peter.langer@uni-rostock.de or Najim A. Al-Masoudi.
najim.al-masoudi@gmx.de
Received November 17, 2012 / published online March 20, 2013
A new series of pyrano-chromene and pyrimido pyrano-chromene derivatives were synthesized starting from 2-amino-4-(1-naphthyl)-5-oxo-4H,5H-pyrano[3,2-c]chromene-3-carbonitrile (6). The structures of the synthesized compounds were elucidated by spectral data. Compounds 6–11, 13–15 and 18 have been selected for an inhibitory activity screening against HIV-1 and HIV-2 in MT-4 cells.
Key words: Anti-HIV Activity, Chromenes, Pyrano-chromenes, Reverse Transcriptase Inhibitors (NNRTIs)