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Z. Naturforsch. 2013,
68b, 168 – 174
doi:10.5560/ZNB.2013-2268
New Crystalline Forms of Piroxicam
Latvian Institute of Organic Synthesis, 21 Aizkraukles street, Riga, LV-1006, Latvia
Reprint requests to Anatoly Mishnev. E-mail:
mishnevs@osi.lv
Received October 12, 2012 / published online February 20, 2013
Four new crystalline forms of piroxicam have been obtained and studied by single-crystal X-ray structure analysis. These comprise an addition salt with hydrochloric acid, acetic and isobutyric acids solvates, as well as piroxicam and furosemide cocrystal acetone solvate. All these new structures contribute to the variety of already known piroxicam crystalline forms. The analysis of conformations and tautomeric forms of piroxicam molecules in different crystal forms is presented.
Key words: Piroxicam, X-Ray Crystal Structure, Crystal Forms, Cocrystals