Z. Naturforsch. 2013,
68b, 201 – 206
doi:10.5560/ZNB.2013-2261
Synthesis and Cytotoxic Activity of Ursolic Acid Derivatives
Dao Duc
Thien1,
Nguyen Thanh
Tam1,
Dinh Gia
Thien2,
Nguyen Thi Hoang
Anh1, and
Tran Van
Sung1
1 Institute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet road, Cau Giay, Hanoi, Vietnam
2 Le Quy Don High School, Tam Ky, Quang Nam, Vietnam
Received September 25, 2012 / published online February 20, 2013
Fourteen ursolic acid derivatives, among them four novel compounds, were synthesized by modification either at the C-3, C-28 or both positions. The cytotoxic activity of the obtained derivatives was evaluated against the four human cancer cell lines KB (human mouth epidermal carcinoma), HepG2 (human hepatocellular carcinoma), MCF7 (human breast carcinoma) and Lu (human lung carcinoma). As the result, compounds 7 and 8 were from two to three times more active than ursolic acid on all four tested cell lines. This is the first report on cytotoxic effects of the synthetized ursolic acid derivatives 4, 8, and 10–15.
Key words: Ursolic Acid Derivatives, Cytotoxic Activity