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Z. Naturforsch. 2012,
67b, 835 – 842
doi:10.5560/ZNB.2012-0122
Nitroimidazoles Part 7. Synthesis and Anti-HIV Activity of New 4-Nitroimidazole Derivatives
1 Department of Chemistry, College of Science, University of Basrah, Basrah, Iraq
2 Fachbereich Chemie, Universität Konstanz, 78457 Konstanz, Germany
3 Rega Institute for Medical Research, Katholieke Universiteit, B-3000 Leuven, Belgium
Reprint requests to Prof. Dr. N. A. Al-Masoudi. E-mail:
najim.al-masoudi@gmx.de
Received May 6, 2012 / published online August 20, 2012
Reverse transcriptase enzyme (RT) is an attractive target for the development of new drugs useful in AIDS therapy and HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs), and offers the possibility of generating structures of increased potency. On this basis, a series of 4-oxo-3-phenyl-2-(phenylimino)thiazolidin-5-ylidene, 3-hydroxypropyl, 3-azidopropyl, and 3-aminopropyl derivatives of 1-benzyl-2-ethyl-4-nitroimidazoles 6–8, as well as the substituted 1,2,3-triazolo analogs 12–14, the diazepam 15 and carboxamide derivatives 16 and 17 were synthesized. All compounds have been evaluated for their anti-HIV activity.
Key words: Anti-HIV Activity, Nitroimidazoles, NNRTIs, Piperazine Derivatives