A B C
Z. Naturforsch. 2012, 67b, 717 – 724
doi:10.5560/ZNB.2012-0090
Ionic Liquid 4-(3-Methyl-1-imidazolio)-1-butanesulfonic Acid Hydrogen Sulfate-catalyzed Synthesis of Phthalazinetrione Derivatives
Shihua Song1, Xiang Deng2, Zhi Guan1, and Yanhong He1
1 School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China
2 Department of Chemistry and Chemical Engineering, Sichuan University of Arts and Science, Sichuan Dazhou 635000, P. R. China
Reprint requests to Prof. Zhi Guan and Prof. Yanhong He. Fax: +86-23-68254091. E-mail: guanzhi@swu.edu.cn (for Zhi Guan); heyh@swu.edu.cn (for Yan-Hong He)
Received March 30, 2012 / published online July 18, 2012
A simple method for the synthesis of phthalazinetrione derivatives by a one-pot three-component condensation reaction of phthalhydrazide, 1,3-dicarbonyl compounds and aldehydes catalyzed by the ionic liquid 4-(3-methyl-1-imidazolio)-1-butanesulfonic acid hydrogen sulfate ([BSO3HmIm]HSO4) is reported. Good to excellent yields were obtained in short reaction times in the solvent PEG 600 (polyethylene glycol 600) at 120 °C. The strategy proved to be efficient and environmentally benign. The catalyst/solvent system could easily be recovered and reused for at least 5 times without noticeable loss of activity.
Key words: Multicomponent Reaction, One-pot, Ionic Liquid, Phthalazinetrione Derivative
Full-text PDF