|
Z. Naturforsch. 2012,
67b, 819 – 826
doi:10.5560/ZNB.2012-0082
Synthesis and DNA-binding Properties of a Cationic Seven-coordinate Manganese(II) Complex Formed with the Tripodal Ligand Tris(N-methylbenzimidazol-2-ylmethyl)amine and Salicylate
School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou 730070, P. R. China
Reprint requests to Prof. Huilu Wu. E-mail:
wuhuilu@163.com
Received March 20, 2012 / published online August 20, 2012
A ternary cationic Mn(II) complex with the tripodal ligand tris(2-(N-methyl)benzimidazylmethyl)amine (Mentb), salicylate and DMF as ligands and nitrate as counterion, [Mn(Mentb)(salicylate)DMF](NO3), was synthesized and characterized by physico-chemical and spectroscopic methods. The crystal structure of the Mn(II) complex has been determined by single-crystal X-ray diffraction and revealed that the central Mn(II) atom is seven-coordinated. The DNA-binding properties of the Mn(II) complex were investigated by spectrophotometric methods and viscosity measurements, and the results suggest that the Mn(II) complex binds to DNA via an intercalation binding mode. Additionally, the complex exhibited potential hydroxyl radical scavenge properties in in vitro studies.
Key words: Manganese(II) Nitrate Complex, Crystal Structure, DNA-binding Properties, Tris(2-(N-methyl)benzimidazolylmethyl)amine (Mentb)