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Z. Naturforsch. 2012,
67b, 491 – 494
doi:10.5560/ZNB.2012-0073
Molecular and Crystal Structure of Sildenafil Base
Latvian Institute of Organic Synthesis, 21 Aizkraukles street, Riga, LV-1006, Latvia
Reprint requests to Anatoly Mishnev. E-mail:
mishnevs@osi.lv
Received March 8, 2012 / published online May 31, 2012
Sildenafil citrate monohydrate, well known as Viagra®, is a drug for the treatment of erectile dysfunction. Here we present the X-ray crystal structure of the sildenafil base, C22H30N6O4S. The compound crystallizes in the monoclinic system, space group P21/c with the unit cell parameters a = 17.273(1), b = 17.0710(8), c =8.3171(4) Å, β = 99.326(2), Z = 4, V =2420.0(3) Å3. A comparison with the known crystal structures of sildenafil citrate monohydrate and sildenafil saccharinate is also presented.
Key words: X-Ray, Crystal Structure, Sildenafil, Viagra