Z. Naturforsch. 2012,
67b, 438 – 446
doi:10.5560/ZNB.2012-0028
Millifolides A–C. New 1,10-Seco-guaianolides from the Flowers of Achillea millefolium
Yong
Li1,2,
Zhi-Yu
Ni1,
Meng-Chu
Zhu3,
Kai
Zhang4,
Yi-Bing
Wu4,
Mei
Dong1,
Qing-Wen
Shi1,4,
Chang-Hong
Huo4,
Françoise
Sauriol5,
Hiromasa
Kiyota6,
Yu-Cheng
Gu7, and
Bin
Cong1
1 Department of Forensic Medicine, Hebei Key Laboratory of Forensic Medicine, Hebei Medical University, 361 Zhongshan East Road, Shijiazhuang, 050017, Hebei Province, P. R. China
2 Department of Thoracic Surgery, Fourth Hospital of Hebei Medical University, 12 Jiankang Road, Shijiazhuang 050011 Hebei Province, P. R. China
3 Laboratory Medical Science, School of Medical Science and Laboratory Medicine, Jiangsu University, Zhenjiang, 212013, Jiangsu Province, China
4 Department of Medicinal Natural Product Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, 361 Zhongshan East Road, Shijiazhuang, 050017, Hebei Province, P. R. China
5 Department of Chemistry, Queen's University, Kingston, Ontario K7L 3N6, Canada
6 Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amamiya, Aoba-ku, Sendai 981-8555, Japan
7 Syngenta Jealott's Hill International Research Centre, Berkshire, U. K.
Received January 27, 2012 / published online May 31, 2012
Ten 1,10-secoguaianolides were isolated from the flowers of Achillea millefolium. Their structures were determined on the basis of spectroscopic methods. Three of them (millifolides A–C) including two dimeric sesquiterpenoids exhibit new skeletons. Seco-tanapartholide A exhibited moderate cell growth inhibitory activity against the human cancer cell line MCF7WT (IC50 = 5.51 μm) in vitro.
Key words: Achillea millefolium, 1,10-Seco-guaianolides, Millifolides A to C, Structure Elucidation, Cell Growth Inhibition